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Who we are |
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Theme of research |
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The modulation of fundamental cellular processes by post-transcriptional and post-translational mechanisms contributes important complexity to expression of the genome, development and behaviour of eukaryotic organisms. We are using the fruit-fly Drosophila melanogaster as a model system to study these post-transcriptional mechanisms and the processes they affect. Two different themes are pursued in our group.
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1) Post-transcriptional Regulation in Drosophila Neurons (Marie-Laure Samson) |
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Our work is centered on understanding the central role played by RNA-maturation events in the nervous sytem. This level of regulation has an impact on the entire neural network, from assembly to function. It involves RNA binding proteins, and affects all steps of RNA processing as well as mRNA stability, localization and translation. We are using as a model system the ELAV family of RNA binding proteins present in all metazoans. MORE...
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2) Signaling by LAMMER Protein Kinases (Leonard Rabinow) |
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Our project concerns elucidating the roles played by the LAMMER protein kinase family in the regulation of alternative splicing, various signaling pathways, and their biological functions. We are using the Drosophila LAMMER protein kinase, encoded by the Doa (Darkener of apricot), locus as our model. These kinases are found throughout eukaryotes and constitute one of the eukaryotic « signature » proteins. They are best known for their role in the regulation of alternative splicing, but our data, as well as that of others, demonstrates that they intervene in additional cellular processes and mediate signaling in several different cascades, affecting cell and organismal differentiation, cell cycle progression and apoptosis. MORE... |
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